Thursday, 15 September 2016

(Ab)normal psychology

In a presidential blogpost at the BPS last month, Peter Kinderman reiterated an argument from his book that there is no such thing as abnormal psychology. I have spoken to this debate once before, when I reviewed his book on this blog. Here is what I said then:
A superficially appealing argument raised here is that "abnormal psychology" is an unreasonable field of study; after all, we don't speak of "abnormal physics". There is an important idea here with which I find myself aligned. Using the word "abnormal" is indeed a needlessly unpleasant way of speaking about people, but the physics analogy doesn't fly. All physical phenomena are subject to the same basic laws (as far as we know), but that hasn't prevented the fruitful subdivision of their study into solid state physics, condensed matter physics, and so forth. When people have experiences of psychological distress, these tend to manifest in a propensity toward particular states of mind. Is it really so unreasonable to study these states in their specificity, cautiously categorising them until some better framework is offered?
I still stand by that more or less, but when I re-read Kinderman's argument this time around I felt more disposed to agree with something in the point he makes. What is he driving at here? It's a fun idea to probe.

Psychiatric diagnoses like schizophrenia can be said to be hypothetical constructs. That is to say they are theories about the nature of entities (what type of entities is controversial) that are held to exist. Because it is still hard to find solid external criteria by which to independently validate their existence, they are sometimes said to fail as valid constructs. This is not a fringe argument. It is acknowledged far and wide within academic psychiatry. That is why the validity/utility debate has such traction within the discipline. I have pointed out before that psychiatric diagnoses survive because they come to act as a sort of stand in term for quite real seeming experiences. Where they aspire (and fail) as hypothetical constructs, they succeed as intervening variables.

What does that mean? In the 1948 paper that introduced and distinguished intervening variables and hypothetical constructs, the former are simply a convenient shorthand for some collection of already observed (but potentially unexplained) empirical facts. The latter are supposed to be things, that have some "explanatory surplus"; if you can propose a successful hypothetical construct, you will be able to make new (and accurate) predictions about reality.

That term explanatory surplus is key. Although there is a way of reading Kinderman's argument that is unfavourable to him (namely that one can of course plausibly divide the study of psychology into common and and relatively uncommon processes), he is certainly on to something. Here are two reasons why:

1. In any given case in which an individual has a psychiatric diagnosis, I can make some rough empirical predictions based on aggregated statistical facts about that diagnosis. But because knowledge about psychiatric entities is generally obscured by how poorly defined they are (for now), I am largely at a loss to make tightly-specified predictions about individuals based on a decent theory. "Abnormal psychology" is a collection of useful observations about how certain people behave and what processes are present in particular groups. 

2. Even if I did have a well specified set of facts about such and such a psychiatric entity, the majority of any given person's behaviour will still be best explained by facts that are common to all people. Thus I can usually understand instances of aggression in terms of things like a person's likely fears and wishes, combined with the situational context they found themselves in. I can then add on some nice sounding post-hockery to the effect that they have "poor impulse control" (a variation on a capacity we all have more or less of) or something similar. In the absence of a well set out aetiological theory of any disorder (giving it "explanatory surplus"), I don't really have an explanation yet. Most people's behaviour (even psychiatric patients) can be mainly explained by principles that have been derived from general psychology. Only a little is added by factoring in the useful observations of psychopathogical research. 

I have to be careful. I am not downplaying the value of clinical psychological research. Nor am I one of those people who wants to deny that there could be something like illness processes present in many cases of DSM diagnosis. I think it is unambiguously clear that abnormal psychology exists in the context of neuropsychology and neurology. But I suppose I agree with Kinderman insofar as I think that most of the behaviour of most people can (and should, as far as possible) be understood in terms of the things that are common to everyone.

Monday, 29 August 2016

Delusions and Verisimilitude

What's the one thing everyone knows about delusions? That they're false beliefs. Not so fast. Already we have two problems. First, there is much debate among philosophers about whether they are really beliefs (recently the linguist Dariusz Galasinski has written a fascinating post about whether delusional utterances even always have to be propositional statements).

Additionally, it's not clear that delusions always have to be false. An oft repeated sentiment in psychiatry is that even a true belief ("my wife is cheating on me") could be delusional if held with the right (or, I suppose, wrong) sort of conviction. That idea is usually attributed to Karl Jaspers, but not having read him yet I can't confirm. I have also seen it attributed to Lacan, but I don't recall coming across it when I read his weird, poetic Seminar on the Psychoses. Perhaps someone could point me to the source.

I am intrigued by the possibility that a true statement could be a delusion. It seems superficially rather a contradiction in terms, after all "delusional" is a rhetorical way of describing something as patently false. Nonetheless it makes some sense. It seems possible to have a pathological conviction about something true. Imagine correctly insisting that it was raining outside when you had no means of knowing it were so. Healthy assertion about most things contains withing itself the germ of the possibility that the person asserting could be wrong.

It seems then that we can be delusionally correct in certain circumstances. Is there also another way delusions could be true? Could they be, as I think some therapists would like to suggest, a form of communication about reality? Could it be that delusions, even quite wild ones ("I am having my mind read by the president"), have some element of truth to them?

Some people think so. For example, one therapeutic approach suggests finding the relate-able component of any delusional utterance and focusing on that. A supervisor recently told me that she was once confronted by a patient yelling "we're at war!" and responded by saying "you must be very frightened". I can't resist the detail that the patient turned out to be flatly correct (it was 2003 and she was referring to the outbreak of the Iraq war), but my supervisor's approach was a good one I think. When someone says something to you that is on-the-face-of-it at odds with your understanding of reality, it seems more communicatively cooperative to find the part that both of you make sense of. "You think other people can read your mind? Well that must feel terrifying and very exposing."

Such an approach sometimes gets packaged up as a form of relativism or pluralism, the idea being that there is no such thing as one truth. That might feel quite comfortable for people of a certain philosophical persuasion; if you are a pluralist or post-modernist about truth, then you needn't be troubled by the idea that any given statement is false.

Image result for this is my truth tell me yours
Do we have to have different truths?

Unfortunately I like the therapeutic stance but not the philosophical posture. I have come to belief in truth. By this I just mean that I think that some states of affairs are the case, while others are not. What is more, I think most people secretly agree. If you jump off a bridge (all other things being equal), you'll end up moving downwards. If there were nothing that were true it would be supremely weird that we managed as a species to agree over so many things.

So what do we do? Can we still say, following sympathetic therapists, that delusions have some truth to them? I think we can. Beyond the idea that some statements are true and others false, there is the idea in philosophy of science, that any given statement can be more or less true; that is, have more or less verisimilitude. Take these two statements: 1. "There is no such thing as schizophrenia" 2. "Schizophrenia is a real illness". They seem mutually contradictory, as though they couldn't both be true. They certainly cause a lot of argument. Regular readers of this blog might already have a view about which is right and which is wrong.

I think such arguments usually arise because the people apt to make one of those statements often think they are saying something that could be simply true or false. This is a mistake. One of the reasons such contradictory statements can exist (and it is surely one of the reasons that relativism about truth is such a respectable position in some circles) is that so many of the claims made in this domain are impossibly under-specified as truth-assertions. That is to say, my example statements 1 and 2 use such loosely understood words ("schizophrenia", "real") that we cannot gauge their truth value without interrogating some hypothetical speaker to get further qualification.  For what it's worth I think both statements have some verisimilitude. I go back and forth about which one I think has more truth than the other, but they are both getting at something basically correct.

How does all this help us with delusions? Delusions are like the statements studied by philosophers of science. They are often (though not always) statements about how the world is. If this were not so we might not bother calling them delusions to begin with. People falsely claim they are being watched; that they are of unusually superior ability; that they are infected with some fatal disease. It seems right to be aware that such beliefs are are often untrue. At least the headline assertion is often false. However delusions are usually complex and under-specified statements. Minimally, a person who makes an outlandish claim about the world is also making a less ridiculous one about what it is like to be them at that moment. Broadening our view somewhat, they might be making a quasi metaphorical statement about some aspect of their environment. I will not be saying anything radically new if I suggest that sometimes, delusions are informative in surprising ways.

Therapeutically this is nothing new. Sympathetic listeners have long held that delusions contain something true. Confronted with an uncomfortable contradiction between a patient's beliefs and their own, many people's instinct seems to be to assert the possibility of a plurality of truths. People of some philosophical persuasions (self included) find this too wishy-washy. Perhaps verisimilitude can help us square the circle. 

Monday, 15 August 2016

Trump: A psychological fiction

Nobody predicted it. A chronic narcissist they said. Mentally unstable. Not fit for office. But 2016 was that sort of year. The unthinkable had happened time and again. In retrospect the rise of Donald Trump to the presidency seems inevitable. Already the succession of events seems pre-destined; a global economic downturn, combined with the shift of manufacturing jobs overseas, guts the white American working class financially, at the same time as the rise of a triumphant cultural liberalism aliented them socially. Trump was able to ride to power on a double wave of anger. The story seems designed for school history books.

It took no time at all for Trump to look seriously out of his depth. What had looked like confident bluster for most of the previous year (and had so pleased that section of the population that had voted for him after years of feeling sick at being condescended to by the "liberal elite") started to lose its sheen even for the Donald's most ardent fans. It was one thing for Trump to swagger onto one of his golf courses in Scotland during the UK's EU referendum. It was quite another to watch him garble his way through his first joint press conference with the proficient Theresa May. For the first time in living memory a US president came second fiddle to a UK Prime Minister. Worse, for former Trump supporters, this was a woman!

Again and again Trump looked foolish. His gaffes piled up; mixing up North and South Korea during his  inauguration address, appearing to think Francois Hollande was the Canadian premier, and of course the unforgettable backtracking on the great Mexico-US border wall as it transpired almost immediately that such a project was utterly unfeasible. Never in history had a president looked so hopeless so quickly after taking office. 

But the really unpredictable part came next in mid 2017. Rumours began to circulate that the joint chiefs of staff were plotting to find some way of dealing with Trump. Not unseating him (a straight coup would have been too de-stabilising for America), but subtly moving to de facto rule by military until the 2020 general election rolled around. Despite America's historical love of democracy, there was a quiet sense that most of the population would have supported such a move. Americans may have been sick of being governed by politics-as-usual career politicians, but they had no wish to see the country driven to complete destruction by someone as nasty and stupid as the president.

Trump's bluster began to falter. For a man with a historical lack of any apparent humility (or capacity for self reflection) he started to seem far quieter. Interviewers noticed a calmer quality. He was famously photographed leaving a briefing in the Oval Office with tears in his eyes. Suddenly Trump's mental health was in question again; tabloids ran crass stories about him losing it; buckling under pressure.

And then the game changing press conference on the White House lawn in September, reading tearfully, but with unprecedented dignity from notes on a lectern. "Fellow Americans, I have a burden I wish to share with you today; the burden of a man who has battled all his life with crippling shame and self disgust." The journalists were aghast. Was this a bizarre trick? A resignation? Had Trump finally gone mad?

He continued:
During my campaign a lot of people threw a lot of diagnoses at me, a lot of hateful terms. That hurt, but I did what I have learned to always do, to shrug it off and roll on. I knew I could ignore the haters, even feed off them. I had never known failure before, not real failure, so I rolled on, thinking I could just keep my head above water. But in my months as president I have learned something profound; something which has changed me more than I can hope to convey to you. Those wannabe doctors throwing diagnoses at me? Well, painful though it was to admit it, I have come to see they were right. Here's what the doctors say they mean by Narcissistic Personality Disorder:
Trump pulled out a piece of paper and read out the DSM-5 criteria for NPD. He laughed at each item on the list, with the Washington press pack (nervously at first) joining in too, sharing with him this unprecedented self-disclosure:

  • Grandiosity with expectations of superior treatment from others
  • Fixated on fantasies of power, success, intelligence, attractiveness, etc.
  • Self-perception of being unique, superior and associated with high-status people and institutions
  • Needing constant admiration from others
  • Sense of entitlement to special treatment and to obedience from others
  • Exploitative of others to achieve personal gain
  • Unwilling to empathize with others' feelings, wishes, or needs
  • Intensely jealous of others and the belief that others are equally jealous of them
  • Pompous and arrogant demeanor
Sounds like me right? Well, at least it sounds like the me of last year, and the me of my entire life up to now. I've been that guy everyone calls 'arrogant'. I've been the pompous entitled guy who bullies and intimidates to get what he wants. But I have to tell you, there is another side to all this that the psychiatry textbooks don't play up; the feeling of vulnerability, shame and goddam self hatred underneath it all!
He was getting tearful again, and across America, so were millions of others too. Blue collar workers who had voted Trump to stick it to the liberal elite; New York intellectuals who had hated Trump and everything he stood for. Blacks. Whites. Latinos. All across the country, people united in shared emotion at the disclosure suddenly being made by the most powerful man on the planet. Trump went on and described the intense feelings of loneliness and shame he had experienced all his life, and which he had protected himself from using a defensive shield of confidence and grandiosity.

What Trump did that day changed America's understanding of mental health, and of Narcissistic Personality, forever. Trump made a radical shift toward collective governmental decision making, openly acknowledging his own limitations; "now I have been open about how I used narcissism to defend myself, I don't have to hide my own lack of knowledge or experience; I can learn! It's liberating, really."  Bullying bosses across rethought their behaviour as the president role-modelled a strong but fallible leader. Books appeared describing that hidden underbelly of narcissism; the fear and insecurity it hides. The American Psychiatric Association revised the DSM to more strongly emphasise that "true self" core underneath the defence. And slowly the term came to have a less insulting ring as the population at large stopped associating it with brashness and arrogance, and held in mind instead that fragile, frightened person underneath to who we can all relate.

As I write this, in 2018 Trump's approval ratings are middling, but there is an unprecedented sense of warmth and respect for someone who, having brought the country to the brink of crisis, managed to weather his own psychic storm to rapidly. Americans have weathered that storm with him, and there is a feeling that somehow leadership has been changed forever. 

Saturday, 6 August 2016

"None of that was real": Folk metaphysics and psychopathology

A brief selection from Irvin Yalom's latest book of psychotherapy vignettes: A newly qualified clinical psychologist (Helena) seeks psychotherapy with Yalom after realising that a recently deceased friend and travelling partner would have met criteria for bipolar disorder. Reflecting on their exhilarating travels together, Yalom’s patient expresses an unsettling worry:

What I used to consider the peak of my life, the glowing exciting center, the time when I, and he, were most thrillingly alive—none of that was real. (Yalom, 2015. Italics in original).

There is a peculiar sort of folk metaphysics on display in this complaint. Helena has just qualified as a clinician and now reinterprets the behavior of a gloriously energetic friend in terms of illness. Perhaps aspects of the friend’s life do make sense in terms his having of a mood disorder, but the idea of such an illness seems to rob some of his experiences of perceived authenticity. Although it is less tangible a harm than stigma, detention or forcible medication, this sense of lost reality seems to be a profound and damaging alteration in conscious experience.

Here in microcosm we see a hint of how people (even clinicians) think about psychiatric disorder categories. Not real. Not mine. Not me. I feel bad for the clinical psychologist's patients. What an impoverished and concrete way she has of thinking about their experiences.

Tuesday, 12 July 2016

Reviewing the Literature: Fiction's Clinical Psychologists

This post is a callback to a talk I saw in March, in which John McGowan from Salomons explored the way psychiatrists are represented in film. With so many villainous psychiatric professionals he asked, is Hollywood ready for a hero psychiatrist? This is a good question to explore. How psychiatrists are represented in film and literature is an index of how they are held in our collective imagination. His survey of recent films suggested something like ambivalence toward the mind doctors. However, psychiatrists have been heroes in the past. The final scene in Hitchcock's Psycho, when Dr. Fred Richman (or Richmond? IMDB is ambiguous here) delivers a confident breakdown of Norman Bates' mental process, is very telling. That was the very early 1960s US, when psychiatrists ruled the cultural interpretation of the mind with their baroque psychoanalytic theories and formulations (until the 1980s they dominated US psychoanalysis as other professionals were excluded from analytic training institutes). Hitchcock's doctor is dashing, fluent and definitive. He is also almost omniscient. What a good thing that we don't hero worship our mind doctors like that anymore!

By now psychiatrists have quite a long and complex place in film and literary history. What about clinical psychologists specifically? You don't find them very much in fiction. Pat Barker once wrote a novel Border Crossing about a child psychologist, and the Sixth Sense's Malcolm Crow is a psychologist too. They may not be heroes, but they are good guys. Sensitive, intuitive and basically virtuous. Often though, clinical psychologists are lumped in under the vague category of mind doctor. You don't really know whether they are psychiatrists, psychoanalysts, psychotherapists, or what. Authors and directors don't really care about the boundaries between psy-professionals that we practitioners like to police so carefully. 

There are two exceptions to this trend that I am aware of. They are revealing because they both tell a similar story. The first is from Norman Rush's incredible novel Mating, which is an epic story of love and the life of the mind, centred on the figure of Nelson Denoon and an unnamed female narrator. The narrator loves Nelson with a sort of respect and passion that can only be conveyed in a reading of the book. She becomes dismayed when, after she crosses the Kalahari desert to join him at a utopian community he has been developing, he develops a sort of passive indifference to ideas and projects he once found important. She enlists the help of a clinical psychologist to try and get him back, but has to grapple with the contempt with which Denoon holds them:



"About as respectable as colonic irrigation"! I found that part smarted a bit. Rush has spent a lot of time getting us to trust Denoon's opinion, and it is impossible to read the novel and not love him yourself. 

Another example is in Will Self's How The Dead Live. Self is very interested in (and skeptical about) the psy professions. His character Mr. Khan is specifically a clinical psychologist (in contrast with one of Self's recurring characters Dr. Zach Busner; a psychiatrist), and seems to have been included as a form of deliberate professional satire. Here he is meeting the novel's main protagonist Lilly Bloom, who is about to die of breast cancer (a fuller excerpt is here, and is worth reading):


Yuck! What an unattractive portrait; albeit one I recognise in real-life descriptions from people who have received help from clinical psychologists. At the risk of denigrating my colleagues, I wonder if there is a grain of truth in Self's unflattering depiction. To a some extent he is wringing a laugh; using a self important professional for comic relief. But satire is a serious business and should make us think about how we are with people, and in what ways we fail to accurately see ourselves in those interactions. I'd be interested to know about any other clinical psychologist appearances in the fictional domain. How else are we perceived and imagined in the culture?

Sunday, 19 June 2016

What do we talk about when we talk about schizophrenia?

I have been gleefully reading Kieran McNally's book on the history of schizophrenia, which turns out to be a compendium of great detail and fascination. As someone who has spent a few years now trying to seriously orient myself in the history of this weird and sprawling concept (I was lucky enough to be allowed to devise and teach an undergraduate course on the history of schizophrenia), I am staggered by the scale of McNally's erudition on the subject. It makes the book enormously valuable both as a treasure trove (in addition to an almost 30 page long reference section, there is a further 10 pages of recommended reading) and as a contribution to our understanding of this unwieldy but influential idea.

The topics of madness and psychiatry have long had their groups of dedicated historians, but the history of schizophrenia itself can get sidelined. Often it is told as part of a broader narrative by people with an axe to grind (witness Jeff Lieberman's casually whig history "Shrinks" from last year), or with other, bigger fish to fry (Richard Bentall's Madness Explained contains a nice conceptual history of schizophrenia, but it is not the main focus of the book). Such histories are, in any case, often predominantly externalist, meaning they focus on the social and economic context of madness (or on the personalities of famous psychiatrists), and not on the development of the ideas. McNally's book is avowedly internalist about schizophrenia. This means you won't find many colourful anecdotes about wacky doctors and their extraordinary patients, but the story of the concept's development (filling a space that has been peculiarly vacant) is no less entertaining. The book is built partly out of papers which McNally has published on specific historical questions, but it still comes together into a satisfying and revealing narrative.

Things Are More Complex Than They Seem:


This is a "critical" history in the best sense of that term; that is, McNally introduces layers of complexity and nuance to a narrative we already think we know. The rough outline of schizophrenia's past is well rehearsed: at the turn of the 19th/20th centuries, Kraepelin separates Dementia Praecox from Manic Depression, and Bleuler re-names it "schizophrenia", partly to avoid the degenerating quality implied by "dementia". Psychiatrists disagree wildly about how to define it, until a series of refinements (Schneider's first rank symptoms, the Feighner criteria) lead into a universally accepted definition in DSM-III. There are two major waves of disruption (Poland's "socio-political" critics in the 1960s, and "scientific" critics from the 1980s to the present), and a future rendered uncertain by the rise of NIMH's RDoC initiative.

Several major strands in this story are unwound by McNally, revealing how official psychiatric knowledge transmission warps the field's history. To begin with, it is convincingly demonstrated that the notion of schizophrenia as "split personality" (which psychiatrists have spent decades defining schizophrenia against) is not some popular misconception perpetrated by an unwitting public but was, for many years, built firmly into the professional understanding of the category. Thus psychiatric textbooks spent about the first 3rd of schizophrenia's lifespan describing it in terms of psychic splitting, and the next two 3rds repudiating that conception.

Officially Hecker's idea of Catatonia (which was incorporated into schizophrenia) has been "disappearing" from the diagnostic scene, possibly because of improved medication. In fact, argues McNally, it may never have been very prevalent, nor very conceptually coherent ("Taxonomy, consequently, made visible to science, in a ceremonial space, categories of people who were not in fact there." - p.95), and was only reluctantly accepted as part of the broader schizophrenia classification in the first place. In another vein meanwhile, the popular Bleulerian mnemonic, the "four As" (disorders of association, affect, ambivalence and autism), is at least an over-simplification of Bleuler's writings, and at worst a distortion. Some texts have five As, and others disagree over what the As actually are. In any case, Bleuler did not write in such glib snippets, and the acronym only appears some fifty years after his text, probably for the benefit of trainee psychiatrists who felt bad that they couldn't find time to read the original.

These are just headline findings. It is not possible to do justice to the richness of the text, which brings out much needed detail from schizophrenia's murkiest period, that space between the appearance of Bleuler's 1911 book, and the emergence of the first DSM. During those forty something years, psychiatrists were particularly divided over what schizophrenia meant, and how it stood in relation to the idea of dementia praecox (which actually survived in some dusty corners until into the late 1960s). Importantly, McNally can read German and French, and can thus go back to original source material in a way that is rarely done. So much of the self-recounted history of psychiatry (Lieberman's book is a prime example) hews closely to the living memory of the teller. Thus anything much before the 1950s has been increasingly excluded from the profession's autobiography.

Ahistorical Psychiatry:


One theme that runs throughout is what McNally describes as "the ahistorical nature of psychiatric thought" (p.126). Psychiatry, he points out, has persistently neglected the development of its own concepts, leading to simplification and dilution of its ideas (some psychiatrists have also lamented this tendency). This is how ideas pertaining to catatonia, split personality, and Bleuler's "four As" can be so awry.

It's tempting to hope this doesn't matter. As Thomas Kuhn pointed out, all successful scientific research is in the habit of forgetting its history ("Why dignify what science's best efforts have made it possible to discard?" - The Structure of Scientific Revolutions, p.138). But it does matter deeply. There is serious doubt about whether psychiatry is a scientific enterprise (a psychiatrist once told me that he had chosen his profession because it was the only branch of medicine prepared to admit it was not a science), and no good can come from simplistic reification of ideas at the expense of describing real experiences. Recent research by Nev Jones has highlighted the peculiar and disquieting effect when people doubt the validity of their experience because it fails to match canonical DSM descriptions. To accurately describe people's subjectivities, psychiatry needs depth, and for all its flaws, the detail one can find in Bleuler's clinical writing conveys a sense of people, and what ails them, that checklist diagnoses are sorely lacking.

Contra Metzl?


It is peculiar that McNally devotes a whole chapter to the issue of how schizophrenia fed into social discrimination, and a section therein to its specific racial biases, but nowhere mentions Jonathan Metzl's The Protest Psychosis. Metzl's thesis is that schizophrenia became a "black disease" during the late 1960s, when DSM-II took away the suffix "reaction" from the diagnosis, and psychiatrists implicitly came to associate paranoid projections (an important concept in understanding psychosis at the time) with the representations of black political activists. Possibly he does not concur with Metzl. By McNally's reading, schizophrenia was already a black disease long before DSM-II or even DSM-I, being over-diagnosed in black populations in studies in 1925 and 1931.


Beyond the Horizon


There is sometimes a sense that McNally over-does the ludicrous quality of schizophrenia research (though, I would hasten to add, not by very much). For instance, in an entertaining early chapter he reviews the extraordinary litany of long forgotten sub-divisions and related concepts. Speaking of a schizaxon, schizothymia, schizomania, schizonoia, schizobulia, schizophasia, shizoparagraphia, or of a schizovirus all seem rather absurd now (especially when you put these schizo prefixes together). McNally groups Meehl's (1962) schizotaxia in with these redundant concepts, painting a picture of one more another junk idea in the scientific dustbin. But although it's fair to point out that no-one now speaks of schizotaxia, it is misleading to suggest that Meehl's idea fell by some historical wayside, just because the term didn't catch on. In teasing apart a conceptual referent for "schizotypy" (a sub-clinical, at-risk phenotype) as opposed to schizophrenia (a clinical disorder) and schizotaxia (a heritable disposition), the framework presented in Meehl's paper provided a powerful organising principle for schizophrenia research ever since. Whether they know it or not, contemporary investigators are indebted to the idea of schizotypy (which is actually very popular right now). Schizotaxia (even if undesirably named) is perfectly conceptually coherent. Nobody now talks in terms of Albert Ellis' "musturbation" (to mean the anxiety provoking feeling that one should achieve some unreasonable thing), but that doesn't mean Albert Ellis didn't play an important role in re-conceiving the function of psychotherapy.

As I mention above, McNally is not interested in pushing an agenda for researchers, though one suspects he thinks they should be more historically literate. However, it's impossible to read this book without wondering about the problem of schizophrenia's conceptual unwieldiness. McNally is, at the very least, skepitical, and wonders in his conclusion whether the side effects of medication are too high a price to pay for treatment given the idea of schizophrenia has "often failed to justify itself" (p.210). The validation of schizophrenia is frequently postponed for the future, a shining technological breakthrough when psychiatry anchors its concepts once and for all. Once again, the idea of abandoning schizophrenia is in the air; should we stop talking about it? Should we call for a paradigm shift? If only it were so simple.

I have argued before that schizophrenia's flaws are undeniable, but we lack a compelling alternative. Paradigm shifts (at least in the Kuhnian sense) take place when a theoretical framework arrives that makes it untenable to speak in terms of its predecessor. Schizophrenia is just over 100 years old, which isn't that long in the tooth for a productive but strictly false programme of research. Phlogiston theory organized research in chemistry from 1667 to 1780, though researchers probably had a sense it was flawed for a while before they could figure out a better way of thinking. Unlike Oxygen theory, none of the competitors currently being mooted in the psychiatric domain (a focus on specific symptoms or complaints, or on individual formulations) is formally incommensurate with a theoretical disorder called "schizophrenia". Until a theory arrives that makes tighter predictive claims, we are stuck with a hot mess.

Friday, 3 June 2016

Medication, Phenomenology and the Nocebo Effect

A great recent paper by Gibson and colleagues undertook a thematic analysis of people's responses to being asked about taking antidepressants. Some of what they described was very negative. This is not a surprise (it is well known that many antidepressants have a significant side effect profile), though it is important that it has been documented. Here, for example, is a striking description:
Each one has had a worse effect than the previous…. I can’t remember them all. It started with memory loss then progressed to me becoming borderline catatonic staring at the wall for hours unable to stand up. Within a few weeks and genuinely terrified. It was a relief to go back to the misery of depression after these experiences
In addition to descriptions of what we can designate as direct negative physiological effects, another negative theme that emerged was "loss of authenticity/ emotional numbing". This is a more slippery experience; a sort of phenomenological unease arising from taking medications. Authenticity is an important part of our sense of who we are. To interfere with it may be less physically dangerous than a side effect like weight gain, but feels somehow more metaphysically perilous. Take my body, but leave my self alone!

The authors of the study point out "This research points to the inadequacy of asking the simple question: ‘Do antidepressants work?’ Instead, the value or otherwise of antidepressants needs to be understood in the context of the diversity of experience and the particular meaning they hold in people’s lives." I agree, but I think even this form of the question can be complicated further.

We have become accustomed to thinking about the effects of antidepressant medications in terms of the placebo effect. Since (at least) a famous meta-analysis by Irving Kirsch (and a subsequent book), many have suggested that the benefits of antidepressants are not the result of an positive, active drug effect, but the mysterious workings of the various expectancy effects we call "placebo".

It's a popular idea, albeit one that has become fraught with controversy. I am not going to wade into the question of how effective antidepressants really are (if you want to think about that then you are in for a long puzzling road. You could do worse than to start with James Coyne's provocative critique of Kirsch here). but I do want to suggest that, when it comes to expectancy effects and antidepressants, there may be a kind of asymmetry in how we customarily think.

Drugs also have nocebo effects; harmful outcomes that arise from the expectations of the people taking them. The nocebo effect (placebo's evil twin) is not something to be fooled around with. For a vivid account read this case study of a young man who needed hospitalisation after he overdosed on the inert pills he was given during an antidepressant trial. If expectations about a sugar pill can do that, then without doubting the flat reality of antidepressants' severe physical effects, we might wonder whether some negative effects, including feelings of phenomenological unease, could also result from a such a phenomenon.

There is a veritable culture of suspicion about the phenomenology of antidepressants, and a strand of cultural commentary on psychiatric medications that sounds a shrill moralising note. Taking medications for depression is regarded by some as an inherently suspect thing to do. Two notorious skeptical pieces in The Guardian (by Will Self and Giles Fraser), around the time of the publication of DSM-5, both hinted at the idea that taking antidepressants was the result of false consciousness:
At worst, they pathologise deviations for normalcy, thus helping to police the established values of consumer capitalism, and reinforcing the very unhappiness that they purport to cure.
It is hard to imagine that none of this would loop back round and influence people's experiences of what it is like to take medication. Ineeded, psychiatrist Linda Gask writes beautifully about the internal struggle over self-authenticity that can result from these ideas:
There are times still when I wonder whether the medicated me I’ve been for so long is the ‘real’ me, or are these tablets simply suppressing the person I truly am?
Contrast the Gibson study with the miraculous seeming accounts of the experience of taking SSRIs when they were brand new. Peter Kramer's 1994 "Listening to Prozac" included the now famous (and oft-derided) claim from one patient that the drug made them feel "better than well".

Could it be that when drugs first appear, they not only benefit from a sort of placebo boost (in virtue of their novelty value), but also from the absence of a culturally inherited, nocebo baggage? Research on this question seems just as important as teasing out the beneficial effects that arise from inert substances. If there are such effects, what are the moral obligations that arise for how we talk about treatments and shape the expectations of those who take them?